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Cuando Jade Beacham descubrió que todo en lo que había creído en su vida había sido una farsa, tomó la decisión de empezar de nuevo y puso rumbo a.
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Language: Spanish. Los cuentos infantiles tradicionales, de la coleccion de los Hermanos Grimm, forman una antologia de cuentos de hadas, fabulas, farsas rusticas y alegorias religiosas. Hasta ahora la coleccion ha sido traducida a mas de idiomas. Los cuentos y los personajes hoy en dia son usados en el teatro, la opera, las historietas, el cine, la pintura, la publicidad y la moda. Los ejemplares manuscritos de Cuentos para la infancia y el hogar propiedad de la biblioteca de la Universidad de Kassel fueron incluidos en el Programa Memoria del Mundo de la Unesco en Tras la Segunda Guerra Mundial y hasta estuvo prohibida la venta de los cuentos de los hermanos Grimm en la zona de ocupacion inglesa, ya que los ingleses los consideraban como una prueba de la supuesta maldad de los alemanes durante la guerra.

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The collection of the samples from HIV-infected patients is located at the beginning of the chain of translational research[ 6 ]. To carry out quality research that could eventually end in a personalized treatment for HIV, it is fundamental to guarantee the availability, quality and traceability under a strict system of quality management of samples obtained through standardized techniques that can be used in studies on AIDS.

Another important characteristic of the BioBank is that it can generate unlimited quantities of genetic material from patients, allowing the use of these samples indefinitely[ 7 ]. The provision of this material is free and only depends on the quality of the research project that must meet the ethical and legal criteria established by the BioBank. The number of samples stored in a BioBank is another relevant aspect required to support the needs of personalized medicine. Therefore, only a large number of samples can provide a sufficient size of specific patients subgroups to be useful for evaluating individual variations of disease[ 6 ].

The excellent traceability of the samples of the distinct HIV cohorts gives investigators the possibility to study subgroups of HIV-patients which are well characterized in distinct stages of the disease and to correctly carry on the evolution of the infection in a group of individuals over a long time period. Furthermore, the large quantity of samples that are available allows researchers to conduct studies with higher scientific and statistical significance.

However, it should not be forgotten that these multidisciplinary tasks can only be fully exploited thanks to the generous donors, who rightfully expect progress to be made in HIV infections using their donations. Therefore, sharing data and samples for good research need to be an obligation for those involved in decisions on access of donor samples. The manager of the sample resource as well as others involved in the decision on the access to the samples in the HIV BioBank are merely the caretakes of the samples and must act in the best interest of the donors.

Therefore, to exploit the full potential of the HIV BioBank, networking between individual biobanks is indispensable[ 3 ]. As a requirement for international cooperation, it is not only necessary to define common standards for sample quality and data formats[ 8 ], but also to consider the differences in ethical, legal and social environments in the different countries of partner biobanks[ 9 , 10 ]. Moreover, BioBank management and governance need to cover a variety of aspects such as compliance with biosafety and biosecurity regulations, as well as keep a balance between sample use and accrual.

Its success is measured as much in publications as in technical and scientific advances achieved via the use of these samples. MAMF had full access to all the protocols in the implantation of system of quality management based on the rules contained in UNE-EN-ISO and supervised its design and execution, performing the final analyses, writing the manuscript.

A ; Hospital de Canarias, Sta. R; Alonso M. F; Gatell, J. A; Aramburu, M. D; Castro, M. I; Campos, R; Castro, J. A; Blanco, J. National Center for Biotechnology Information , U. Journal List Retrovirology v. Published online Mar 9. Author information Article notes Copyright and License information Disclaimer. Corresponding author. Received Feb 2; Accepted Mar 9.

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This article has been cited by other articles in PMC. Abstract Background The collection of samples from HIV-infected patients is the beginning of the chain of translational research. Results At the moment, the HIV BioBank possesses nearly 50, vials containing different prospective longitudinal study sample types. Conclusion The HIV BioBank represents a novel approach to HIV research that might be of general interest not only for basic and clinical research teams working on HIV, but also for those groups trying to establish large networks focused on research on specific clinical problems.

Correspondence Advances in research and technology allow for the design of new experimental approaches to use the same biological specimens that have previously given positive results. Table 1 Participating patients in sample donation to the HIV Research BioBank and the date of creation and the sample types donated and for each cohort. Open in a separate window. Competing interests The authors declare that they have no competing interests.

References Gottweis H, Zatloukal K.

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Biobank governance: trends and perspectives. Sample, data use and protection in biobanking in Europe: legal issues. Biobanking for interdisciplinary clinical research. Whole genome amplification on DNA from filter paper blood spot samples: an evaluation of selected systems. Genet Test. Summit calls for clear view of deposits in all biobanks. Evaluation of biobank constitution and use: multicentre analysis in France and propositions for formalising the activities of research ethics committees.

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Eur J Med Genet.